Mucolytic treatment with N-acetylcysteine L-lysinate metered dose inhaler in dogs: airway epithelial function changes

Mucolytic treatment with N-acetylcysteine L-lysinate metered dose inhaler in dogs: airway epithelial function changes.

N-acetylcysteine L-lysinate Nacystelyn (L-NAC) is a newly synthesized mucolytic agent, of which the action in vivo has not been well defined. In six healthy mongrel dogs, the rheological properties of mucus, its mucociliary and cough clearability, and the transepithelial potential difference (PD) of the tracheobronchial epithelium were evaluated after placebo and L-NAC metered dose inhaler (MDI...

Salmeterol administration by metered-dose inhaler alone vs metered-dose inhaler plus valved holding chamber.

STUDY OBJECTIVE To determine whether a spacer device designed as a valved holding chamber with a flow signal increases the efficacy of the long-acting beta(2)-agonist, salmeterol, in patients who use incorrect technique with metered-dose inhaler (MDI) alone. DESIGN Double-blind, randomized, placebo-controlled study. SETTING University hospital outpatient rooms. PATIENTS Twenty adult outpa...

Metered dose inhaler with spacer in children with acute asthma.

Principles of metered-dose inhaler design.

The pressurized metered-dose inhaler (pMDI) was introduced to deliver asthma medications in a convenient and reliable multi-dose presentation. The key components of the pMDI device (propellants, formulation, metering valve, and actuator) all play roles in the formation of the spray, and in determining drug delivery to the lungs. Hence the opportunity exists to design a pMDI product by adjusting...

Salmeterol + Fluticasone propionate Seretide Metered Dose Inhaler

PRODUCT DESCRIPTION Salmeterol + Fluticasone propionate (Seretide) 25/50mcg Metered Dose Inhaler: Each single actuation provides salmeterol xinafoate equivalent to 25mcg of salmeterol and 50mcg of fluticasone propionate. Salmeterol + Fluticasone propionate (Seretide) 25/125mcg Metered Dose Inhaler: Each single actuation provides salmeterol xinafoate equivalent to 25mcg of salmeterol and 125mcg ...